Blake, who was the clear favourite for the title in the absence of the now retired Usain Bolt, made a dreadful start as he stuttered horribly out of the blocks.
Simbine was able to capitalise with a solid run, taking gold in an underwhelming winning time of 10.03 seconds.
It was a South Africa one-two as Henricho Bruintjies took silver, leaving a hugely disappointed Blake to settle for bronze in 10.19 seconds.
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"I stumbled at the start. I lost from the start," Blake told the BBC.
"It would have been a good way to get back on top. It's really frustrating for me."

Akani Simbine of South Africa celebrates winning gold with silver medalist Henricho Bruintjies of South Africa after the Men's 100 metres final during the Athletics on day five of the Gold Coast 2018 Commonwealth Games at Carrara Stadium

Image credit: Getty Images

England's Adam Gemili was forced to withdraw from the final earlier in the day with injury after failing to shake off an injury he sustained in the semi-final.
Michelle-Lee Ahye claimed the women's 100m gold for Trinidad and Tobago in 11.14 seconds ahead of the Jamaican charge.

Michelle-Lee Ahye of Trinidad and Tobago celebrates as she wins gold ahead of Christania Williams of Jamaica and Asha Philip of England in the Women's 100 metres final during the Athletics on day five of the Gold Coast 2018 Commonwealth Games

Image credit: Getty Images

Christania Williams (11.21 seconds) took silver, with her Jamaican team-mate Gayon Evans picking up the bronze.
England's Asha Philip was fourth in a time of 11.28 seconds and was desperately disappointed with the result.
"I came fourth in Glasgow, fourth in Australia, it seems to be my favourite number," Philip told the BBC.
"I'm better than this. That's just shocking to be honest, I should have done better than that."
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