The 27-year-old Venezuelan, who also won the award in 2004, collected all 28 first-place votes for the award to total 140 points. New York Yankees right-hander Chien Ming Wang of Taiwan was second in the voting, gathering 15 second-place votes to 12 for third-placed Roy Halladay of the Toronto Blue Jays.
Santana, who also won the award in 2004, was 19-6 and led the majors in earned run average (2.77), strikeouts (245) and tied for first in wins to give him the Triple Crown of pitching. He also led the AL in innings pitched with 233 2/3.
Santana battled through after a split nail and a blister on his pitching hand during the year as well as a sore hip and sore back.
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But he responded magnificently when the Twins made a charge into the playoffs after a slow start, posting a 10-1 mark with a 2.54 ERA in 15 starts after the All-Star break.
Even when Santana did not figure in a decision, the dazzling southpaw contributed to good things for the Twins, who posted a 27-7 record in games with him on the mound.
Santana helped the Twins to their fourth AL Central title in the past five years under manager Ron Gardenhire before they were ousted in the Divison Series by the Oakland Athletics.
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