On Tuesday night, the four seeds - TAU, Unicaja, CSKA, and Panathinaikos - all earned massive home victories which put them in complete control of their best-of-three contests and one step away from the Final Four.
TAU destroyed Olympiacos, but the Greeks will be desperate to hang on, as the Final Four is in Athens.
Pini Gershon's side welcomed back Arvydas Macijauskas for his first competive appearance since pre-season in the first match, but he is still too early into his rehabilition to been seen as their savour.
Instead, they will need Scoonie Penn to step-up, as he was kept scoreless in the first match.
Olympiacos beat TAU at home by 19 points in the opening game of the regular season, but the Basques go into this game holding all the aces, as they have won their last nine Euroleague games and are gunning for their third successive Final Four.
Last season CSKA beat Maccabi in the final, and they will be hoping to end Tel-Aviv's interest in this year's competition much earlier.
The Israeli have only lost once at home all season, and have been in the last three Euroleague finals, but they are coming up against a red hot team who hammered them on Tuesday, who have won 18 straight Euroleague games, and who have only lost once all season on the road.
Dynamo Moscow need to improve their outside shooting if they hope to join their city rivals in the Final Four, they shot just 2 for 16 from three point range in their heavy defeat to Panathinaikos on Tuesday.
The Greeks had a strong performance from Ramunas Siskauskas in that game with his 16 point performance showing that three weeks out injured did him little harm.
While in the all Spanish game, Barcelona look perhaps the best placed of the unseeded teams to take their contest to a game three.
They were beaten heavily by Unicaja Malaga on Tuesday too, but they did at least lead until near the end of the second quarter and they are more experienced than their visitors who have never been to a Final Four.
You can follow LIVE scoring and comments of all four games here on eurosport.com