Tau Ceramica clinched first place and home-court advantage in the quarter-finals with a huge 94-73 win over Maccabi Tel Aviv .
History was also made as power forward Luis Scola scored 25 points to become the all-time Euroleague top scorer.
Scola took his total to 1,998 while the third player on the list, Maccabi center Nikola Vujcic, scored only six to give him 1,774 for his career.
As if one record wasn't enough, Tau also set a Euroleague mark with 26 straight home wins - they last lost at home in January 2005 against CSKA, 81-85.
Maccabi made an impressive 95% of their free throws, but despite that they finished with their second-worst Euroleague defeat all decade.
Pau-Orthez scraped a close 74-69 win over Roma but it was not enough to see them move from the bottom of the group.
Melvin Sanders was outstanding in the first two-quarters for Pau-Orthez, but he went off of the boil towards the latter minutes of the game, which coincidentally saw Roma take the lead.
Sanders then missed two late free throws which could have helped the home team build up momentum towards a much needed ten-point lead.
Olympiacos overcame a late challenge from visiting Partizan to secure a crucial Euroleague Top 16 win 79-75 thanks to the late heroics of Alex Acker.
Acker, who finished the night with a game-leading 25 points, hit a critical three-pointer to put the hosts up by three with less than a minute left to play.
The win sees the Reds improve to 2-2 in Group E, which returns them to the forefront of the battle for a spot in the Quarterfinal Playoffs. Meanwhile Partizan now have a 1-3 tally and consequently sees their chances of survival start to slip away.
CSKA Moscow topped Group E after a rampant 73-65 win over DKV Joventut. John Robert Holden racked up 17 points which included three three-pointers.
Despite his poor free throw stats Matjaz Smodis was outstanding in every other department - stealing balls and scoring important two-pointers.
Credit to defending Champions Joventut they fought until the end, but it wasn't enough against CSKA who have won their 15th consecutive game.