Fresh off of his victory in the one-day Belgian semi-classic Le Samyn GP, Casper again outsprinted the field in Belgium.
The 2006 race victor Eeckhout finished second in the 170-km stage from Kortrijk to Bellegem, and his Belgain compatriot Wouter Weylandt (Quick Step) took third.
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The 28-year-old Casper, who won the opening stage of the Tour de France last year, now leads the general classification at the Driedaagse van West-Vlaanderen.
Casper finishes the job
Tour of Murcia
Brown takes sprint