The Unibet rider finished five seconds ahead of young Belgian Quickstep rider Wouter Weylandt in the overall classification.
Weylandt took the final stage of the race by winning a bunch sprint after after all attempts at breakaways were reeled in.
Tour of Turkey
Cavendish claims stage hat-trick at Tour of Turkey after huge crash
Stefan Van Dijk of Team Wiesenhof Felt finished third overall, while last year's winner Nico Eeckhout could only manage a 4th place finish this time around.
"Excited and a little bit nervous" - Jakobsen ahead of cycling return
Tirreno - Adriatico
Alaphilippe takes Stage 2 after stunning finish at Tirreno-Adriatico