The 2000 champion roared away from an escape group with 30km remaining and crossed the finishing line over a minute clear.

The 33-year-old Acqua & Sapone rider also won Saturday's stage in Bergamo.

The 189km stage from Agordo took a long time to come to life with the peloton happy to take things easy in morning rain.

Benoit Joachim (Astana) and Laurent Mangel (AG2r Prévoyance) finally launched an attack with 70km to go and a lead group of 13 formed as the riders faced rolling hills just after crossing the Austrian border.

But Garzelli felt strong enough to jump out of the peloton and succesfully bridged the gap to the leaders, Mangel, Pietro Caucchioli (Crédit Agricole), Ricardo Serrano (Tinkoff), José Luis Rubiera (Discovery Channel) and Pablo Lastras (Caisse d'Epargne), just before the start of the third category ascent of the Bannberg 27km from the end.

The bald headed Italian wasted little time as he went past the quintet and built a significant lead before tackling a 17km circuit of the Tyrolean city.

The chase group failed to make any inroads and Mangel eventually led them home 1:01 behind with the peloton crossing eight minutes behind.

Danilo Di Luca of Liquigas retained the overall lead as the riders prepare for Wednesday's crucial stage that concludes at the formidable summit of the Monte Zoncolan.