The 37-year-old made her decisive move with around 20 kilometres left, breaking away from a lead group that included defending champion Chantal van den Broek-Blaak (Boels–Dolmans) and her team-mate Gracie Elvin.
Van Vleuten opened up a gap of 15 seconds after descending off the Muur-Kapelmuur, and that lead only widened as she eventually crossed the finish line.
Marta Bastianelli finished second, with Floortje Mackaij third.
World Championships
Defending champion Van der Breggen pulls out of World Championships time trial
14/09/2021 AT 15:53

Highlights: Van Vleuten goes solo to win Omloop

1Annemiek Van VleutenMitchelton Scott3:34:55
2Marta BastianelliBtc Ljubljana0:00:42
3Floortje MackaijTeam Sunweb
4Chantal Van Den Broek-BlaakBoels Dolmans Cyclingteam
5Ellen Van DijkSegafredo0:00:44
6Elizabeth BanksKatusha0:01:13
7Eugenia BujakAle' Btc Ljubljana
8Chloe HoskingRally Cycling0:01:30
9Jip Van Den BosBoels Dolmans Cyclingteam
10Aude BiannicMovistar Team Women
Van Vleuten secures overall Ladies Tour of Norway victory as Hosking sprints to Stage Four win
15/08/2021 AT 14:25
Tour of Norway
Van Vleuten takes win on Queen's Stage to take control of GC in Norway
14/08/2021 AT 16:16