Super-domestique Mikel Nieve was forced to abandon the Tour de France during Wednesday Stage 17.
The 36-year-old Spaniard had been aiding Adam Yates on the mountain stages, but the Mitchelton-Scott team leader will be without his strongest deputy for the remainder of the Tour.
It is the first time Nieve has failed to finish a Grand Tour, with him making it to the end of all previous 18 Tours in his career.
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Nieve has six top ten finishes to his name in Grand Tours and had never finished lower than 25th in the Giro, Vuelta or Tour, earning him a reputation as one of the leading super-domestique's in world cycling.
He was 48th going into Wednesday's Stage 17.