Should the Brussels side slip up against cup-finalists Waregem, a win for second-placed Standard Liege at home to Ghent will see them claim their first league trophy in 23 years. Liege claimed back-to-back titles in 1982 and 1983.
Anderlecht, who last won the title in 2004, go into their final game top of the table on 67 points, two points ahead of Liege. Anderlecht's goal difference is plus 42, compared to Liege's plus 25.
The race for third place and a UEFA Cup spot also goes down to the wire. Last year's champions Club Bruges are third on 61 points and entertain Racing Genk knowing they must at least draw to be certain of European football next term.
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If Bruges lose then Ghent, who held Anderlecht to a scoreless draw last week, are waiting to pounce. Victory for Ghent, three points behind Bruges, at Liege will see third place decided on goal difference.
The title winners go into the Champions League group stage with the runners-up entering the third qualifying round of Europe's elite club competition. The team finishing third enters the UEFA Cup second qualifying round.
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