Former Bayern Munich coach Hansi Flick signed a two-year contract on Tuesday to take over Germany after the end the European Championship this summer, the German Football Association (DFB) said.
"Everything happened surprisingly quickly for me and I am happy to be national team coach from the autumn," Flick, who was the frontrunner for the post, said in a statement.
Flick led Bayern to six titles in the 2019/2020 season and also won this season's Bundesliga crown but decided to leave the champions after 18 months in charge.
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Low's Germany crashed out in the first round in the 2018 World Cup and has been struggling to perform at the highest level despite an overhaul.
A 6-0 thrashing by Spain in the Nations League in November was Germany's worst defeat in competitive football.
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