Run-away League 1 leaders Lyon host the second League Cup semi-final at the Stade de Gerland reeling from their surprise 2-0 defeat in Toulouse.
Le Mans, ninth in Ligue 1, beat Sochaux 2-1 in their quarter-final tie thanks to an inspiring performance by Brazilian striker Grafite, who is injured for Wednesday's clash.
Coach Hantz feels his young side can carry through their momentum from the last tie despite the absence of their star player, the away disadvantage and their underdog image.
"My only regret is Grafite's absence, but I think the experience of our victory at Sochaux is going to help us," Hantz told French paper Ouest-France.
"Our group is young but ambitious and very together.
"The first quarter of an hour will be very difficult because Lyon will try to show that they have forgotten their defeat at Toulouse.
"The atmosphere won't help us - there will be 35,000 fans cheering on Lyon. But we will have five million fans rooting for us from behind their TVs because people always feel affection for the small sides.
"It might be nearly mission impossible for us but that is why people love sport - to see unexpected upsets and great performances."
Le Mans face a fixture congestion which will see them play five games over the next two weeks, including a mouth-watering clash against Marseille in the last-16 of the French Cup.
On Tuesday night Bordeaux became the first club to qualify for the League Cup final after edging Stade Reims 2-1.
The final will be played in the Stade de France on March 31.
Round-up: PSG held by Lyon