Looking for his first home win of the season, Paris St Germain coach Paul Le Guen is banking on youth in a bid to upset Ligue 1 leaders Lyon at the Parc des Princes.
He is expected to try the same tactic against Lyon and defender Bernard Mendy believes it could work.
"Paul knows what he's doing," Mendy said. "This match could be the turning point we're waiting for."
Monaco are looking to halt a run of five straight losses, something that has not happened to the side in over 40 years.
"I've never found myself in such a complicated situation in my entire career," said Monaco's Brazilian coach Ricardo, whose team welcome promoted Caen on Saturday.
Monaco executive director Marc Keller said the team from the principality had fallen victim to poor refereeing decisions.
"We know we're not good enough but the officiating has been going against us and that's hard to swallow," Keller told L'Equipe.
Bottom-side Metz are hoping their fans will behave when they entertain second-placed Nancy in an eastern derby on Saturday.
During their last home match, a 2-1 defeat to another eastern club, Strasbourg, a handful of Metz fans fought with the visiting supporters.
Nancy's Brazilian forward Kim has resumed training after nursing a thigh muscle strain and should play.
The young France playmaker had been sidelined for three weeks with meningitis.
Struggling Lens welcome back midfielders Julien Sable and Eric Carriere for Sunday's home match against third-placed Stade Rennes after they recovered from injury.