Bottom side Paderborn, who secured a scoreless draw away to Fortuna Dusseldorf last week, got off to the worst possible start when Danish international Skov netted for the visitors after just four minutes.
But a dreadful blunder by Hoffenheim defender Ermine Bicakcic five minutes later gifted the ball to Paderborn's Srbeny, and the striker curled home for the equaliser.
Despite plenty of chances in an open, free-flowing game, neither side could manage another goal. The draw leaves Paderborn bottom of the table on 18 points, while Hoffenheim are ninth on 36. (Reporting by Philip O'Connor; Editing by Hugh Lawson)