Southampton’s Alexandre Jankewitz was sent off after just 79 seconds, Jan Bednarek also walked, and Arsenal had David Luiz and goalkeeper Bernd Leno sent off in a crazy Premier League evening.
Arsenal were cruising 1-0 up at Wolves before David Luiz conceded a penalty in first-half added time and was given a red. Ruben Neves then scored from the spot to level the scores.
A brilliant Joao Moutinho goal gave the home side the lead, and the three points, just after the restart, but Arsenal had no chance when goalkeeper Bernd Leno later elected to run out of his box to needlessly slap away a long ball instead of using another part of his body to clear.
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"With Leno, there are zero excuses for him," said former Manchester United defender Rio Ferdinand on BT Sport.
"He's misjudged the bounce of the ball and then from there it's just comedy."
That wasn’t the only reckless act of the night, as Jankewitz started his Southampton career disastrously.
Less that two minutes into Southampton’s game against Manchester United at Old Trafford, when the 19-year-old midfielder launched his studs in United midfielder Scott McTominay’s thighs, and Mike Dean issued a straight red with no hesitation.
United took the lead on 18 minutes through Aaron Wan-Bissaka as Southampton struggled to contain the hosts before Ole Gunnar Solskjaer's side ran riot.
With the score at 6-0, Southampton were then reduced to nine men just as Arsenal had been, when Bednarek was dismissed for a professional foul on Anthony Martial in the box. United went on to score three more times to equal the Premier League record for the biggest winning margin.
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