Best known for hiring and firing managers at will, Zamparini said a mixture of long-standing Italian bureaucracy and the effects of the global economic crisis had weakened the ability of Italy's top clubs to compete with the continent's best.
"Italy has always been 20 years behind the rest," Zamparini told Reuters. "Spanish and English clubs have stadiums, spend more than us and are able to maintain larger debts. We don't spend, so players leave.
"Once, big Italian clubs used to buy; now we sell, look at [Samuel] Eto'o, and it shows in our results in Europe. Also, our league is among the ugliest to watch because it's very tactical. The Spanish, English and even the French offer better entertainment".
Italy's fall from grace means only the top two clubs in Serie A this season will automatically qualify for the Champions League with the third-placed side in the final qualifying round.
The fourth spot was taken away from Italy and given to Germany's Bundesliga.
"We are losing income against the other big leagues," says the Rosanero chief. "Juventus have their stadium, which is very nice, but stadiums are a great defect for us.
"In Italy you need 10 years to get permission to construct anything. You need eight years to get the okay. We hope to do it in two. If they allow us, we will do it".
Palermo, who are one of two Italian clubs already knocked out of the Europa League before the group stage, have made an impressive start to the Serie A campaign under new coach Devis Mangia, and go into Saturday's match at the San Siro against champions AC Milan lying fourth in the table.
Zamparini, who confirmed his no-nonsense reputation by axing Stefano Pioli before the former Chievo boss had even sat down for a league game this season, may have claimed more than 30 coaching victims in his time as president of Venezia and Palermo, but his on-field success and ability to execute club finances speaks for itself.
Since taking over from Franco Sensi as chief in 2002 with the Rosanero languishing in Serie B, Zamparini oversaw promotion and UEFA Cup/Europa League qualification in six of the past eight seasons, while balancing the budget thanks to a canny ability in the transfer market.
Luca Toni to Fiorentina, Edinson Cavani to Napoli and, most recently, Javier Pastore to Paris St-Germain are some of the players that Palermo have profited from.
"There's no special philosophy," said the 70-year old, who presided over the Sicilian side's best-ever finish in 2010 when they ended fifth. "We've focused on bringing in young players from Italy and abroad. It's the only way to compete against the big clubs because we don't have their revenues.
"We fish in international markets for our young stars, in South America and Africa - it's the same philosophy that Udinese have. We buy players who may go on to bigger clubs like Pastore, though his type comes around once every 20 years".
"That's why Palermo doesn't have any debt. I made an initial investment, and now the club has to balance its books on its own merit. We may be up one year and down the next but our aim is to break even".
Despite enjoying just a quarter of Inter's annual revenue in 2010, Palermo's wage/turnover ratio stood at 64 percent, according to Gazzetta dello Sport, compared to Inter's 104.
While Inter's president Massimo Moratti has had to cut back with UEFA's Financial Fair Play system looming, Palermo, who along with Lazio and Napoli have helped usher in greater financial efficiency to Serie A, could well profit from the rules aimed at levelling the playing field among European clubs.
Zamparini, however, sees it as more interference from the grey corridors of power in Switzerland.
"It's just the usual stupid things that bureaucrats working behind desks think of because they've got nothing else to do," he said, arguing the case that the measure may simply maintain the existing hegemony among Europe's elite clubs.
"I don't think it will make it fairer. What difference does it make if someone decides to invest 100 million euros? There's still competition and there's more money given to football so it wins out anyway".
While Palermo finished eighth last season and reached the final of the Coppa Italia, attendances have been falling with the Renzo Barbera stadium seldom filled to capacity.
"The economic crisis has hurt," he says. "And with television, people don't go to the stadiums because they're like prisons with turnstiles, fences and controls.
"If you're not among those top clubs who get Champions League money, it's very difficult to catch up. Every ten years there's the chance that one or two clubs can break through into the top four like Udinese and Napoli but staying there is hard".
An entrepreneur currently involved in building a major shopping centre near Palermo, Zamparini has set his sights this season on the Europa league: "The Champions League would be a miracle because there are stronger teams around," he said.