Hirving Lozano struck twice as Napoli thrashed Genoa 6-0 on Sunday to begin their Serie A campaign with back-to-back victories.
The Mexico international drilled in a close-range volley after 10 minutes to give Gennaro Gattuso’s side a narrow lead at the interval, but captain Lorenzo Insigne limped off with a muscular problem.
Piotr Zielinski finished off a flowing team move within a minute of the restart, before Dries Mertens was left with time and space to fire in a shot from the edge of the area.
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Lozano then slotted home his second before substitutes Eljif Elmas and Matteo Politano piled on the misery for Genoa with well-taken finishes.
Genoa's preparation was hindered by positive COVID-19 tests for goalkeeper Mattia Perin on Saturday and midfielder Lasse Schone on Sunday.
The victory sends Napoli to the top of the table with six points and a +8 goal difference from their opening two matches, while Genoa are 11th with three points.
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Earlier on Sunday, newly-promoted Spezia suffered a Serie A debut to forget as they fell to a 4-1 defeat against Sassuolo.
The Ligurian club must play the first few home games of their maiden top-flight season more than 300 kilometres away in Cesena while their home ground, the Stadio Alberto Picco, is restructured to meet Serie A standards.
Striker Andrey Galabinov made history with Spezia's first Serie A goal after 30 minutes to cancel out a superb Filip Djuricic opener, but the visitors raced to a comfortable victory after the break.
Hellas Verona defeated Udinese 1-0 thanks to Andrea Favilli's second-half strike.