Archie White, Mark Lambert, Jack Clifford, Luke Wallace and James Chisholm went over for first-half tries and Ben Botica added two conversions as Conor O'Shea's side took a 29-3 lead into the interval, with Filippo Buscema replying with a penalty.
Matthew Hopper crossed 15 minutes into the second half and Botica added a third conversion before the hosts got their only try through flanker Mata Mbanda and Matteo Minozzi converted.
Ireland beat England at Twickenham to secure grand slam
17/03/2018 AT 16:51
Kyle Sinckler and Charlie Walker then added to Quins' try tally and Botica converted both.
England hold on for narrow win over Wales
10/02/2018 AT 18:51
England call up scrumhalf Wigglesworth
05/02/2018 AT 17:09