The Pumas have drafted in Leicester prop Marcos Ayerza (pictured) for Rodrigo Roncero, Alberto Vernet Basualdo for Mario Ledesma at hooker, Manuel Carizza for Mariano Sambucetti at lock and Alejandro Campos for Tomas Leonardi at flanker.
They have also recalled London Irish scrum-half Alfredo Lalanne for Agustin Figuerola, while Federico Martin Aramburu has come in for Mauro Comuzzi on the wing.
Argentina, who have not lost at Murryfield since 1990, are looking to bounce back from defeats in their opening two tour games against England and Wales.
Team: 15-Horacio Agulla, 14-Lucas Borges, 13-Gonzalo Tiesi, 12-Martin Rodriguez, 11-Federico Martin Aramburu, 10-Santiago Fernandez, 9-Alfredo Lalanne; 1-Marcos Ayerza, 2-Alberto Vernet Basualdo, 3-Martin Scelzo, 4-Manuel Carizza, 5-Patricio Albacete, 6-Alejandro Campos, 7-Alejandro Abadie, 8-Juan Martin Fernandez Lobbe (capt).
Replacements: 16-Agustin Creevy, 17-Rodrigo Roncero, 18-Estaban Lozada, 19-Tomas Leonardi 20-Agustin Figuerola, 21-Benjamin Urdapilleta, 22-Horacio San Martin.