France head the table on points difference from Ireland and England, and will have a good idea of what is required after second-placed Ireland meet Italy in the first game of the day.
Bernard Laporte's side lead the Irish on points difference - plus 42 points to plus 38 - while England are third with a difference of just plus 13. England face Wales in Cardiff in the final game of the championship.
Following their shock to defeat to England last weekend, Laporte has replaced winger Christophe Dominic with Cedric Heymans (pictured), while Pierre Mignoni replaces Dmitri Yachvili at scrum-half.
The third change to the side sees Lionel Beauxis come in for the injured fly-half David Skrela.
Scotland appear confident of causing an upset after naming the biggest back-line in Scottish rugby history.
Centres Rob Dewey and Andy Henderson, and wings Nikki Walker and Sean Lamont represent a back-line of considerable size, and skipper Chris Paterson is confident they possess the fire-power to trouble the French.
"You have to take the game to France and what better way of doing it than going straight into them and putting them under pressure from the start," said Paterson, who moves to full-back in the absence of injured Hugo Southwell.
"I don't think many defences will relish playing against the size of backline we have, and hopefully it's another avenue that Frank is looking to explore before the World Cup."
Scotland coach Frank Hadden has named Rory Lamont at scrum-half instead of Chris Cusiter, while Johnnie Beattie comes in at number eight for Dave Callam.
The other change sees Ross Ford preferred at hooker to Dougie Hall.
France: Clement Poitrenaud (Toulouse); Vincent Clerc (Toulouse), David Marty (Perpignan), Yannick Jauzion (Toulouse), Cedric Heymans (Toulouse); Lionel Beauxis (Stade Francais), Pierre Mignoni (Clermont); Olivier Milloud (Bourgoin) Raphael Ibanez (Wasps, capt), Pieter De Villiers (Stade Francais), Lionel Nallet (Castres), Jerome Thion (Biarritz), Serge Betsen (Biarritz), Imanol Harinordoquy (Biarritz), Julien Bonnaire (Bourgoin).
Replacements: Sebastien Bruno (Sale), Nicolas Mas (Perpignan), Pascal Pape (Castres), Elvis Vermeulen (Clermont), Jean-Baptiste Elissalde (Toulouse), Damien Traille (Biarritz), Christophe Dominici (Stade Francais).
Scotland: C Paterson (Edinburgh, capt); S Lamont (Northampton), R Dewey (Edinburgh), A Henderson (Glasgow), N Walker (Ospreys); D Parks (Glasgow), R Lawson (Gloucester); G Kerr (Borders), R Ford (Borders), E Murray (Glasgow), N Hines (Perpignan), S Murray (Edinburgh), S Taylor (Edinburgh), J Beattie (Glasgow), K Brown (Borders).
Replacements: D Hall (Edinburgh), A Jacobsen (Edinburgh), J Hamilton (Leicester), A Hogg (Edinburgh), C Cusiter (Borders), M Di Rollo (Edinburgh), R Lamont (Glasgow).