The 27-year-old Leicester centre picked up the injury in training and will be replaced by Sale wing Chris Ashton on the bench for the opening November test at Twickenham.

Tuilagi, who last played for England in 2016, has endured a wretched four-year run of injuries.

England's bonus-point win in Italy enough for Six Nations win
31/10/2020 AT 18:58

"Manu's disappointed. He desperately wanted to play for England again," scrum coach Neal Hatley said.

Eddie Jones won't stop England fans singing 'Swing Low, Sweet Chariot'
25/07/2020 AT 09:08
Six Nations
England's Marler must avoid being embarrassment to the team - Woodward
09/03/2020 AT 10:15