Akani - who was beaten by Selby last month - secured one of the biggest results in his career as he beat the world champion 6-3 in China.
The Thai sensation made two centuries in the last three frames to claim a memorable victory and book a second-round clash with Zou Yuelong.
Defending champion Selby admitted his mind was elsewhere when defeating Li Yuan in 6-5 in round one on Sunday - owing to the tragic events in his hometown Leicester over the weekend - but the world number one thrashed Doherty 6-0 to book his place in the second round.
'Phenomenal Selby stopped Murphy playing in final' - White
World number one Mark Selby.
Image credit: Getty Images
It was a statement of real intent from Selby as the former world champion Doherty was humiliated with three centuries and two fifties.
Selby is going for three-in-a-row having also won the tournament in 2016, and he will now face fellow Englishman Robert Milkins for a place in the last 32 after his 6-2 win over Noppon Saengkham.
Selby produces stunning century against Doherty
Elsewhere, home favourite Ding Junhui's hopes of reaching the latter stages are still intact after he beat Zhang Anda 6-4, while Judd Trump is also through after whitewashing Alan McManus 6-0 earlier on Monday.
Trump won the inaugural International Championship back in 2012 which gave him a brief spell at the top of the world rankings, and the world number five was in ominous form to book a date with Michael Holt in the next round.
Mark Allen was taken all the way by Liam Highfield before sealing a 6-5 win, while Michael Holt hit a break of 140 in a 6-4 win over Luo Honghao. Marco Fu kept his nerve to edge past Andrew Higginson in a final-frame thriller with the Hong Kong player's break of 52 finally proving decisive.
After Kyren Wilson was beaten 6-2 by Yuan Sijun, English Open champion Stuart Bingham was another surprise casualty after he lost 6-3 to Israel-born Scot Eden Sharav at the third ranking event of the season in the country.
The winner of the event will pocket a cool £175,000, and still in the running is the Australian Neil Robertson after his convincing 6-1 win over Matthew Selt.
Liang Wenbo 4-6 Ian Burns
Anthony McGill 4-6 Stuart Carrington
Mark Davis 3-6 Joe Perry
Fan Zhengyi 2-6 Xiao Guodong
Barry Hawkins 6-2 Thepchaiya Un-Nooh
Martin Gould 6-1 Li Hang
Jack Lisowski 6-1 Chris Wakelin
Jimmy White 0-6 Yan Bingtao
Tian Pengfei 3-6 Ryan Day
Peter Lines 4-6 Martin O'Donnell
Tom Ford 6-3 Jimmy Robertson
Craig Steadman 3-6 Mark King
Matthew Stevens 6-4 Jordan Brown
Zhao Xintong 5-4 James Wattana
Sam Baird 2-6 Alfie Burden
Graeme Dott 3-6 Hossein Vafaei
Kurt Maflin 0-6 Ali Carter
Michael Georgiou 1-6 Stephen Maguire
He Guoqiang 1-6 Zhou Yuelong
'He broke me' - Emotional Murphy on loss to 'super-granite' Selby
'He hid round the corner!' - Selby reveals bizarre distraction on final black