Lurz - formerly Liebs - set a new meet record on her way to winning the 200m freestyle in a time of 1:57.48.
She also clocked 55.54 - tied with teammate Petra Dallman - in the 100m freestyle, beat Olympic champion Yana Klochkova over the 400m medley and claimed the 200m backstroke.
Phelps breaks own record
German Lurz is one of the new wave of European swimmers - along with teammate Britta Steffen, French teenager Laure Manadou and Italian Alessia Fillipi - looking to challenge the dominance of the Australian women in the pool when the World Championships begin on March 25th.
Coughlin: Break the records if you want the title
Olympic champion Luo retires