The world number two and top seed had been scheduled to face Ukrainian qualifier Anhelina Kalinina in the first match of the evening session, but pulled out with what the WTA website described as a right leg injury.
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The match would have been the first of the Dane's North American hardcourt campaign, leading up to the US Open.
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Wozniacki was replaced in the draw by Belgian lucky loser Ysaline Bonaventure.
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