The 39-year-old Frenchman holds a nine point lead over SEAT Sport team-mate Gabriele Tarquini in the drivers' standings and if he gains 12 more points than the Italian in Japan, he will take an unassailable lead into the final race of the season in Macau on November 16.
Tarquini's cause has not been helped after the Monza stewards imposed a five grid position penalty for the first race in Okayama after an illegal manoeuvre in Italy.
Three-time defending champion Andy Priaulx of Guernsey needs a miracle if he is to stay in the title hunt as he trails Muller by 34 points with only 40 more available.
ROAL return to WTCC
Winning four races on the trot has never been done by a driver in the WTCC and fellow Brit Rob Huff also faces a mammoth challenge with the Chevrolet star third in the title chase and 31 points adrift of Muller.
Huff remains upbeat, telling The Sun: "Okayama is a new track for all of us but I think it's going to suit my car. And everyone knows anything can happen in the final two races at Macau as the track is so very tight."
This is the first time the FIA WTCC has visited Japan since the series was revived in 2005 although in 1987, the first edition of the World Touring Car Championship came to a dramatic end at the Fuji Speedway.
Klaus Ludwig and Klaus Niedzwiedz drove their Eggenberger Ford Sierra RS500 to victory in the InterTec 500km but the title went to Roberto Ravaglia at the wheel of a Schnitzer Motorsport BMW M3.
In 1996, the FIA International Touring Car Championship also visited Japan with Mercedes drivers Dario Franchitti and Bernd Schneider taking a win apiece.
A host of new faces will be on show this weekend with the Liqui Moly Engstler Team entering a third car for Japanese driver Masaki Kano, SEAT Eurocup prospect Norbert Michelisz driving a SUNRED SEAT León Tfsi, Hong Kong driver Matthew Marsh joining the Wiechers-Sport team and Melvin Choo competing in the Thunder Asia BMW 320si and becoming the first Singaporean to join the Championship.
Watch live coverage from Japan on your PC via the Eurosport player - click on the link under the picture to subscribe. Or watch the action on British Eurosport - available in the UK on Sky channel 410 and Virgin Media channel 521 or British Eurosport 2 - available on Sky 411 and Virgin Media 525
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