And as Friday progressed several more clubs joined the growing list of those in partial self-isolation, with Everton, Bournemouth and West Ham confirming they had taken the precaution.
Everton confirmed that one player had gone into self-isolation after reporting a high temperature.
"To clarify our earlier statement, Everton Football Club can confirm that one member of the Everton first-team squad reported a high temperature last night and is now undertaking a period of self-isolation for seven days," read their statement.
"In line with Government guidelines no other players are self-isolating at this stage but the Club's USM training facility has been closed as a precaution and staff, including players, have been advised to stay away from all club sites until further notice."
While West Ham took the decision after a number of their staff had come into contact with Arsenal boss Arteta.
"Due to members of West Ham personnel being in direct contact with the Arsenal manager at our game at Emirates Stadium at the weekend, the club is taking a precautionary approach and those individuals are now self-isolating, in line with Government health guidelines," West Ham said..
"The club will work with Public Health England regarding the welfare of our colleagues, their families and our supporters, which is of course our main priority at this time, and also in relation to our facilities, as well as continuing to work closely with the Premier League."
Bournemouth added that Artur Boruc and four members of staff has been placed in isolation despite not testing positive for the virus.
"Goalkeeper Artur Boruc, along with four first team members of staff, are self-isolating in line with Government and Public Health guidelines. This is a precautionary measure as, at this stage, none have tested positive for coronavirus," said Bournemouth in a statement.
That followed news on Thursday that three Leicester City players had been placed in quarantine as a precaution, and the ongoing crisis prompted the Premier League to suspend the league until April 4 earlier on Friday.