The Welsh club scored 16 tries, converting 12 of them, to register a huge 104-12 win - their record European score and winning margin.
Lloyd Williams could not have known what he was starting when he dotted down in the seventh minute and he would score again, with Richard Smith grabbing a hat-trick of tries and Ellis Jenkins a pair.
Also getting over on a humiliating evening for the Italians were Josh Turnbull, Rhys Patchell, Sam Hobbs, Cory Allen, Macauley Cook, Scott Andrews, Kristian Dacey, Gareth Davies and Lewis Jones.
Leicester stay alive with win
Gareth Davies and Gareth Anscombe kicked the Welsh side's points while Matteo Maran, Francesco Menon and Denis Majstorovic got Rovigo on the scoresheet.
Myler kicks Northampton to Challenge Cup glory
Bath edge past Wasps into final