The final league positions will be calculated based on a "best playing record formula" which will decide promotion and relegation, with unbeaten Championship (second tier) leaders Newcastle Falcons set to be promoted to the Premiership.
"We believe that the decisions made provide fair and balanced outcomes for the game and maintain the integrity of the competitions," RFU President Peter Wheeler said in a statement.
"We have listened to recommendations from the heart of the game and the approach has been ratified by the RFU Council."
Newcastle rugby director Dean Richards takes his Falcons side to Gloucester on Saturday
Image credit: PA Sport
Wheeler said they were forced into the decisions due to the "most unprecedented of circumstances", with no single solution suiting every club.
"With 80% of the season complete for the community game, we believe our approach is fair and the right one for our leagues," Wheeler added.
"We have clubs that are clear league leaders and those who have said they would benefit from relegation to play more meaningful rugby."
Second-placed Ealing Trailfinders, who trail Newcastle by 18 points, said last month they were seeking legal advice as they still had a chance of catching the leaders -- a move slammed by Newcastle's director of rugby Dean Richards.
The women's Premier 15s season was declared null and void since it has no promotion or relegation.
The RFU said the final league tables would be available on Friday.