Here is a guide to what will be tested out in Milan...
Like the following week's ATP Finals in London, the tournament will feature two groups of four with round-robin action followed by semi-finals and the final.
Medvedev, Rublev lead Russian Tennis Federation to Davis Cup glory
There the similarity ends.
SCORING AND PLAY
All matches will be best-of-five-sets but with sets played up to four games with a tiebreak at 3-3. Sudden-death deuce points will add to the drama while on-court shot clocks will keep matches rattling along at a fast pace with the 25-second rule rigidly enforced by the umpire.
There will also be no 'lets' on serve meaning play continues when a serve clips the tape and goes in.
Players will also be able to communicate with their coaches via headsets at the end of each set.
The tournament will feature non-stop, on-site entertainment, including cutting-edge match production.
Fans will also be able to move freely around the stadium during play rather than having to wait until change of ends to enter the stands.
The court will have no doubles lines which will also enhance the visual effect for fans in the venue and on TV.
ELECTRONIC LINE CALLS
Line judges peering down the lines will be absent as computers make the calls. The chair umpire will be the only match official on court with calls of 'out' and 'fault' being made by an "automated" voice. Foot faults will be determined by an off-court official. There will be no Hawkeye reviews - a popular innovation in tennis.
Inaugural Next Gen ATP Finals line-up
Image credit: Getty Images
WHY ARE THE ATP DOING IT?
Chris Kermode, the ATP Executive Chairman and President, said: "We're excited to be bringing something new to the table with this event. The sports and entertainment landscape is changing rapidly, as are the ways in which fans are consuming our sport. This event is not only about the next generation of players, but also about the next generation of fans.
"We've created this new tournament precisely to allow us to look at some potential new elements, in a high-profile environment."
WHO IS PLAYING?
Andre Rublev, 20, (Russia) - ranked 37
Karen Khachanov, 21, (Russia) - ranked 45
Borna Coric, 20, (Croatia) - ranked 48
Denis Shapovalov, 18, (Canada) - ranked 51
Hyeon Chung, 21 (South Korea) - ranked 54
Jared Donaldson, 21, (U.S) - ranked 55
Daniil Medvedev, 21, (Russia) - ranked 65
Gianluigi Quinzi, 21, (Italy) - wildcard
Great Britain and Serbia awarded wildcards for Davis Cup 2022 finals
Swiatek splits from coach Sierzputowski after almost six years