Kenin, the seventh seed, triumphed 6-7(2), 7-6(5), 6-4 and continues her good firm, having reached the fourth round of a Grand Slam for the first time at Roland Garros last month, including an eye-catching win over Serena Williams.
Kenin was forced to dig deep in the second set, being forced to save three championship points at 6-4 before eventually emerging victorious in a two hour and 42 minute marathon.
Opinion: No multiple major winners again, but Barty’s 2021 season should be given more respect
"This is such an amazing place. I love coming here," she said after the win.
"This is my special tournament and I look forward to coming back here in many years to come."
Kenin has enjoyed a breakout year. She claimed her first career title against Anna Karolina Schmiedlova in Hobart and defeated fourth seed Elise Mertens and second seed Anastasija Sevastova in the quarter-finals and semi-finals respectively.
Laver Cup, Indian Wells, ATP & WTA Finals: What's left of the 2021 tennis season?
Emma Raducanu: How Britain’s greatest underdog pulled off stunning triumph