Lyon beat Brestois 3-2 on Friday to go top of Ligue 1 on Friday.
Lucas Paqueta, Houssem Aouar and Memphis Depay found the back of the net in the opening half to put OL on 55 points from 26 games, ahead of second-placed Lille on goal difference.
Lille travel to Lorient and third-placed Paris St Germain, who have 54 points, host Monaco on Sunday.
Crystal Palace sign defender Andersen from Lyon
Brest, who pulled two back through Brendan Chardonnet and Irvin Cardona in an entertaining second half, are 12th on 31 points.
Keeper Sebastien Cibois tried to dribble past Paqueta in the box but the Brazilian dispossessed him and tapped the ball into the empty net to put the visitors ahead after nine minutes.
Some poor defending by Paul Lasne then led Aouar to double the tally from inside the area in the 29th minute and Depay added a third from the penalty spot after being brought down by Cibois one minute from the interval.
Chardonnet reduced the arrears with a header eight minutes into the second half and Cardona fired home after beating the offside trap with 16 minutes left.
'I expect to win a lot of trophies' - Depay's first days at Barcelona
Liverpool and United to battle Arsenal for Aouar transfer - report