Bailey-Cole made a slow start out of the blocks at Hampden Park but his long stride helped him claw his way back into the main group at the midway point.
With 10 metres remaining he got on the shoulder of England's Adam Gemili and powered past him to take victory.
Gemili took silver in 10.10 seconds while Jamaican Nickel Ashmeade claimed the bronze in 10.12.
Commonwealth Games
Omanyala, Thompson-Herah win 100m gold titles at Commonwealth Games
03/08/2022 AT 21:07
[FIRST SENIOR MEDAL FOR GEMILI]
Kemar Bailey-Cole ensured Jamaica reigned supreme on the track again by winning the 100 metres gold medal in the Commonwealth Games on Monday.
Earlier, Blessing Okagbare stormed to victory in the women's 100 final in a Games record 10.85 seconds.
The blonde Nigerian made an explosive start before finding her elegant stride to ease away from the rest of the field with 30 metres to go.
Jamaican Veronica Campbell-Brown, cleared in February of a doping violation after appealing against a two-year ban, took the silver ahead of compatriot Kerron Stewart.
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